Advanced Genomics in Pharmacogenomics- AdGen Pharma^TM

Many commonly used drugs are effective only 40 to 60% of the patient population, up to 15% of hospitalized patients experience serious adverse drug reactions and more than 100,000 deaths are annually to such reactions. Patients with most common and cancers like brain tumors, breast cancer, and leukemia receive very aggressive treatments and very often have serious side effects and most often are not effective. The very same medicine works wonders for some people but can be ineffective or even toxic to others. The reason for this is that as medicines find their way to the target site in the body, so many things happening along the way. One reaction triggers another and medicine that should work, mask the symptom. Individual’s metabolism also plays big role. Every individual metabolize drugs differently. Variations (SNPs) in the genes of an individual make different proteins and as drug travels through the body, it interacts with many of these proteins. Genomic research in drug discovery has paved the way for targeted therapies and personalized medicine. Genetic variations affect the metabolism and pharmacological activity of drugs.

Advanced Genomics at Research and Discovery Platform:

Advanced Genomics at Research and Discovery Platform is using SNPs and gene expression analysis for:

• Assessment of drug toxicity and efficacy
• Selection of lead candidate for drug discovery
• Development and screening of compounds through cell based and biochemical assays
• Sort out the patients best suitable for particular drug and therapy

Advanced Genomics at Complete Solution Platform: Advanced Genomics provides platform for development of tools for early diagnosis of certain conditions and for identifying molecular targets for therapeutic interventions. Advanced Genomics is working with partners for developing some of the pharmacogenomics tests for the prevention and assessment of drug treatment and therapy:

Prognostic and Diagnostic Biomarkers Discovery: At Advanced Genomics, we use gene expression signatures to explore the underlying biology of a disease or drug response, to understand the various mechanisms and manifestations of disease.

Theranostic Biomarkers Discovery: We also identify biomarkers in monitoring response to therapy. We use gene expression study to stratify patients into groups likely to respond to the mechanism of therapy and to distinguish responders from non-responders of the therapy.